During the metabolism of fructose, fatty acids in your liver and skeletal muscle tissues can lead to insulin resistance or hepatic steatosis even without alcohol intake. It is clear that insulin resistance sets the stage for the development of prediabetes and subsequently diabetes.
The ingestion of glucose inhibits the secretion of ghrelin (hunger hormone) and stimulates the secretion of leptin, which curbs appetite.
On the other hand, fructose has no effect on ghrelin and interferes with brain communication signals related to leptin, preventing the perception of satiety. It is obvious that it is not fructose alone that is responsible for the excess weight that is becoming more and more frequent in our populations. However, avoiding foods that contain fructose can help maintain a healthy figure.
Apart from this problem of excess weight, the consequences of fructose ingestion on health are enormous and unsuspected. Recent studies count more than thirty diseases and health problems related to it. Especially since fructose is in most cases extracted from transgenic corn. We develop the consequences of GMOs in other articless. This has been well demonstrated recently by Professor Gilles-Éric Seralini through the making of his film "Tous cobayes".