Berberine, an ally in the repair of the intestinal mucosa

Known and used in Chinese and Indian pharmacopoeia for over 2500 years, berberine extract is traditionally advised in the accompaniment of type II diabetes, to improve the capacity of glucose absorption by the cells but also as an antifungal, anti-inflammatory and repairing of the intestinal walls. Discover berberine as a remedy of choice to counter intestinal hyperpermeability. 

La berbérine

The berberine is an alkaloid from certain plants such as barberry found under our lettuces. An alkaloid is an alkaline chemical with real therapeutic value. 

The berberine is therefore an interesting molecule that is particularly advised during the mucosal repair phase in cases of intestinal porosity

Berbérine et la porosité intestinale

Billions of bacteria populate our intestines and participate in the proper functioning of our digestion, the assimilation of nutrients as well as the quality of our immune system. When the balance of this microbiota is disturbed, and this over the long term, the intestines are likely to become porous, thus promoting certain inflammatory and/or allergic disorders.

Where does intestinal hyperpermeability come from?

A diet too high in glucose and low in fiber has a deleterious impact on the balance of the gut ecosystem. Refined sugar is a scourge in our modern societies. Consumed in excess, it participates in the increase of obesity, diabetes, fungal diseases, is also considered a pro-inflammatory food and greatly disrupts various biological and chemical mechanisms of the body.

Repair with berberine before reseeding probiotics

Reseeding probiotics to intestines with inflamed and porous walls is like putting a coat of paint on a cracked wall...

First of all, it is advisable to plug the crack, to seal the breaches before renovating. It is the same in the management in the accompaniment in disorders associated with intestinal permeability.

It is recommended to work first on repairing inflamed damaged walls, then on tissue regeneration, and then re-seeding with good quality probiotics. This first part can last several weeks or even months depending on the intensity of the disorders. 

How does berberine work?

La berberine The berberine prevents the release of toxins from bacteria . It facilitates the development of "good" bacteria in the intestines while blocking "bad" ones. 

De plus, ses propriétés anti-inflammatoires permettent de calmer l'inflammation des tissus de la muqueuse intestinale. Ainsi, elle sera conseillée dans les troubles digestifs tels que :

  • Crohn's disease

  • ulcerative colitis

  • celiac disease 

  • hyperperpermeability intestinal (with repercussion on other organ systems)

La berberine sous l’œil des scientifiques

Several scientific studies report the effectiveness of this molecule in the disorders described above thanks to the stimulation of the enzyme AMPK (Adenosine Monophosphate activated Proteine Kinase) which plays a very important role in the regulation of metabolism. 

Acting directly in the heart of the cell, berberine :

  • Would lower blood glucose levels (hypoglycemic) by decreasing insulin resistance, increasing the ability of cells to break down glucose (glycolysis) and decreasing sugar production in the liver.

  • Would participate in the repair of epithelial cells of the small intestine..

  • Would have significant antifungal, anti-inflammatory and antioxidant properties.

  • would dissolve lipids, decrease the level of "bad" cholesterol (LDL) and promote weight loss.

Quels autres usages avec la berbérine ?

La berberine présente de nombreux atouts santé notamment dans les cas de :

  • diabetes type 2

  • polycystic ovarian syndrome (PCOS)

  • cancer

  • cardiovascular protection

  • cholesterol

  • premature aging

  • depression

  • antioxidant and anti-inflammatory

  • antibacterial

Berberin dosage and side effects

Dans les ouvrages, il est recommandé de prendre entre 900 et 1500 mg de berbérine par jour, 30 minutes avant le repas. Cette molécule a cependant la particularité d'avoir une demi-vie de plusieurs heures. Il faut donc étaler la prise en plusieurs fois par jour afin d'avoir des taux sanguins suffisants. 

If you are already on medication, please talk to your doctor or pharmacist.  La berberine peut causer des désordres digestifs aux personnes sensibles


La berbérine, actif végétal reconnu 

In conclusion, the berberine is a plant active recognized in the management of type 2 diabetes thanks to its hypoglycemic power. However, its interest is just as important in the accompaniment of inflammatory and allergic disorders due to intestinal porosity and this with an adapted diet. 

Santi-shop recommande la berbérine du laboratoire Perfect Health Solutions.

Alexia Bernard 27 September, 2021
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